During this lecture we will discuss what the oral microbiome is and how an imbalanced oral microbiome can cause local effects such as perio and decay as well as systemic downstream effects such as low grade chronic inflammation and bacterial superinfection. I can cover the most recent research into the mouth body connections like heart disease, diabetes, Alzheimer's and infertility and how these mechanisms work. I can then discuss how we as clinicians can test the oral microbiome and how we can integrate the use of things like supplementation and probiotics to improve our patients' outcomes.